Prednisone & Weight Gain (The Studies) Many studies have been conducted to evaluate the side effect profile of prednisone and similar corticosteroid medications. Most of these studies have concluded that prednisone's side effects are generally mild, and generally are not detrimental to the recipient (Barker 2000). These studies include 2 studies from the U, prednisone weight loss side effect.S, prednisone weight loss side effect. and 2 studies from Canada (McNair 1999; McNair 2000), prednisone weight loss side effect. One of these studies has the highest quality of data. In this study, 12 participants with mild to moderate weight loss (5 to 10 kg, 1 to 4% body fat) taking prednisone and/or placebo experienced a decrease in the number of painful episodes, prednisone weight gain stories. The number of days of pain in the last 10 days in the prednisone group was reduced by 20%, while in the placebo group it was increased by 60%, prednisone weight loss first week. In addition, it had been established by this study that a prednisone regimen led to decreased risk of adverse drug reactions (Pelham et al. 1998). A study from the Netherlands included 9 people who had lost 18 to 36% of their body weight, with mean lost weight of 12, prednisone weight loss first week.2 kg, prednisone weight loss first week. One group lost weight while taking prednisone, while the other underwent placebo treatment (De Groot et al, prednisone weight loss side effect. 1998). After a mean of 24 weeks, it was determined that the prednisone group experienced more pain during the last 6 months, however, those with prednisone (45%) reported significantly fewer of these episodes than those who took placebo (54%), weight loss after prednisone taper. Another study from the Netherlands included eight people who lost 18 to 36% of their body weight, with mean lost weight of 18.6 kg. One group received placebo, while the other underwent oral prednisone (Vandenbergh et al. 1999), prednisone weight gain or loss. After a mean of 48 weeks, the prednisone group continued to report significantly fewer painful episodes as compared with those taking placebo (52% vs. 91%) (De Groot et al. 1999). Similar to this study, a study involving a single patient also demonstrated that prednisone was associated with less frequency of acute painful episodes in a single patient (Baumel et al, prednisone weight loss first week. 2001). Overall the weight loss studies conducted by McNair and others have concluded that the use of oral prednisone leads to greater weight loss than using an over the counter or weight loss supplement (Heilbronn 1988), prednisone weight loss side effect. Although the number of studies has been relatively less in other countries, it does include 2 studies in Canada (McNair 1999; McNair 2000), and 1 study from the U, prednisone weight loss side effect.S, prednisone weight loss side effect. (Foley 1999).
Prednisone & Weight Gain (The Studies) Many studies have been performed to gauge the side effect profile of prednisone and comparable corticosteroid drugs. It has been demonstrated that prednisone is less prone to decrease bone density than older anticoagulation brokers whereas rising blood strain, coronary heart fee, physique temperature, and respiratory tract activity (the research of a person with a chronic coronary heart illness confirmed that sufferers with prednisone-induced elevated blood stress and heart rate and body temperature had been significantly extra more probably to have problems than those taking anticoaglimics on the identical time). It ought to be noted that the number of prednisone-treated patients was relatively small so the results could not generalize to all sufferers (Sutcliffe et al, prednisone weight gain stories., 1998), prednisone weight gain stories. Moreover, many studies have indicated that prednisone does not decrease muscle strength due to its nonaltering effects on thyroid hormones (Hammack et al., 1993; Haggard et al., 1996; Kupers et al., 2000; Schott et al., 2001; Schumacher et al., 2001). It has been documented that when corticosteroids are given for a protracted period prior to surgical procedure, the effect of a single cortisone dose may be misplaced by the point the endocrinologic rebound takes place (Mann et al, can you lose weight while on steroids., 2011), can you lose weight while on steroids. Also, it was recently reported that the prolonged use of prednisone causes weight acquire (Kröger et al, prednisone weight gain or loss., 2010), prednisone weight gain or loss. The use of a combination of prednisone and insulin in an overweight patient is more prone to trigger weight acquire when the dose of insulin is used (Stieber and Ziegler, 2000). The use of a single prednisone injection and glucose tolerance tests is more prone to produce weight achieve than the usage of a mixed hypoglycemic and insulin therapy (Bauer et al., 1982). Hypoglycemia (pre-diabetes) has been found to extend the risk of weight achieve when used concomitantly with prednisone in obese patients during a examine by Stieber et al, losing weight while on prednisone. (Kröger et al, prednisone weight gain or loss., 2010), prednisone weight gain or loss. There are a couple of research which have tried to quantify the impact of hypertriglyceridemia on weight gain (i.e., the utilization of triglycerides as marker) (Hammack et al., 1993; Haggard et al., 1996; Haggard, 2000; Stieber and Ziegler, 2000; Strubler et al., 2002).
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